Conditions, Lifestyle Factors & Interventions: Recent submissions
Now showing items 21-40 of 910
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Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
(2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder A Systematic Review and Meta-Analysis
(2023-10)Importance Stimulants (methylphenidate and amphetamines) are often prescribed at unlicensed doses for adults with attention-deficit/hyperactivity disorder (ADHD). Whether dose escalation beyond US Food and Drug Administration ... -
From awareness to action: an urgent call to reduce mortality and improve outcomes in eating disorders
(2023-10)High mortality rates and poor outcomes from eating disorders, especially anorexia nervosa, are largely preventable and require urgent action. A national strategy to address this should include prevention; early detection; ... -
Impaired subjective organisation of memory in psychogenic amnesia
(2023-08)Objectives: Psychogenic or dissociative amnesia is a rare condition which involves primarily impairment in episodic autobiographical memory. Why such impairment occurs in such patients has always perplexed researchers and ... -
Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan
(2023-10)Background: Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural ... -
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
(2023-09)Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia. An important development is provided by ... -
Automated virtual reality cognitive therapy versus virtual reality mental relaxation therapy for the treatment of persistent persecutory delusions in patients with psychosis (THRIVE): a parallel-group, single-blind, randomised controlled trial in England with mediation analyses
(2023-09)Persecutory delusions are a major psychiatric problem that often do not respond sufficiently to standard pharmacological or psychological treatments. We developed a new brief automated virtual reality (VR) cognitive treatment ... -
Complex relational needs impede progress in NHS Talking Therapies (IAPT): implications for public mental health
(2023-10)Although influential in “Increasing Access to Psychological Therapies” (IAPT), the IAPT initiative is predicated on at least two assumptions (namely, homogeneity of clinical pathology and level of severity) that have been ... -
Testing the combination of Feeling Safe and peer counselling against formulation-based cognitive behaviour therapy to promote psychological wellbeing in people with persecutory delusions: study protocol for a randomized controlled trial (the Feeling Safe-NL Trial)
(2023-10)Persecutory delusions are strong threat beliefs about others’ negative intentions. They can have a major impact on patients’ day-to-day life. The Feeling Safe Programme is a new translational cognitive-behaviour therapy ... -
The bidirectional association between psychiatric disorders and sheltered homelessness
(2023-09)Psychiatric disorders and homelessness are related, but temporal associations are unclear. We aimed to explore the overlap between hospital-based psychiatric disorders and sheltered homelessness. Methods This ... -
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
(2023-08)Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ... -
Emotion regulation in children (ERiC): A protocol for a randomised clinical trial to evaluate the clinical and cost effectiveness of Mentalization Based Treatment (MBT) vs Treatment as Usual for school-age children with mixed emotional and behavioural difficulties
(2023-08)The majority of children referred to Child and Adolescent Mental Health Services (CAMHS) in the UK will present with mixed emotional and behavioural difficulties, but most mental health treatments are developed for single ... -
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.
(2023-08)Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living ... -
Cognitive predictors of stress-induced mood malleability in depression
(2023-09)Basic attentional control, negative biases in attention and interpretation, and rumination are all cognitive processes associated with depression; however, less is known about their predictive role in depressive mood ... -
Experiences of Inclusive School Settings for Children and Young People on the Autism Spectrum in the UK: a Systematic Review
(2023-08)Increasing numbers of Children and Young People on the Autism Spectrum (CYP-AS) are attending inclusive education settings in the UK, yet research about the impact on their psychosocial well-being is scarce. This qualitative ... -
Clozapine and Sweet's syndrome: case report
(2023-09)A patient developed fever, raised inflammatory markers and a maculopapular rash following commencement of clozapine for treatment of his schizoaffective disorder. Skin biopsy confirmed Sweet's syndrome. Identification of ... -
New guidance for self-harm: an opportunity not to be missed
(2023-11)In this editorial we, as members of the 2022 NICE Guideline Committee, highlight and discuss what, in our view, are the key guideline recommendations (generated through evidence synthesis and consensus) for mental health ... -
Investigating self-blame and trauma symptoms in parents of young people with anorexia nervosa.
(2023-08)Background: Caring for a young person with anorexia nervosa (AN) has been associated with psychological distress and found to be a traumatic experience. This can have an impact on patient and family outcomes. Objective: ... -
Are current guidelines overcautious regarding refeeding of patients with severe anorexia nervosa: a retrospective cohort study
(2020-05)Weight restoration is an integral part of managing anorexia nervosa patients and has been found to be associated with electrolyte and fluid abnormalities gathered under the umbrella term refeeding syndrome, which has led ... -
The Western diet: a blind spot of eating disorder research?—a narrative review and recommendations for treatment and research
(2020-07)Over the last 50 years, in parallel with the obesity epidemic, the prevalence of eating disorders has increased and presentations have changed. In this narrative review, we consider recent research exploring the implications ...
