Predicting motor, cognitive & functional impairment in Parkinson’s

Abstract

Objective: We recently demonstrated that 998 features derived from a simple 7-minute smartphone test could distinguish between controls, people with Parkinson’s and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity/specificity values of 84.6-91.9%. Here, we investigate whether the same smartphone features can be used to predict future clinically relevant outcomes in early Parkinson’s.Methods: A total of 237 participants with Parkinson’s (mean (SD) disease duration 3.5 (2.2) years) in the Oxford Discovery cohort performed smartphone tests in clinic and at home.Each test assessed voice, balance, gait, reaction time, dexterity, rest, and postu-ral tremor. In addition, standard motor, cognitive and functional assessments and questionnaires were administered in clinic. Machine learning algorithmswere trained to predict the onset of clinical outcomes provided at the next 18-month follow-up visit using baseline smartphone recordings alone. The accu-racy of model predictions was assessed using 10-fold and subject-wise cross validation schemes.Results: Baseline smartphone tests predicted the new onset offalls, freezing, postural instability, cognitive impairment, and functional impair-ment at 18 months.For all outcome predictions AUC values were greater than 0.90 for 10-fold cross validation using all smartphone features. Using only the 30 most salient features, AUC values greater than 0.75 were obtained.Interpretation: We demonstrate the ability to predict key future clinical outcomes using a simple smartphone test. This work has the potential to introduce individualized predictions to routine care, helping to target interventions to those most likely to benefit, with the aim of improving their outcome.