Browsing Dementia by Issue Date
Now showing items 1-20 of 33
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Treatment of Inappropriate Sexual Behavior in Dementia
(2016-08)Inappropriate sexual behavior (ISB) is a relatively common and potentially disruptive form of behavior in people with dementia. It can cause considerable distress and put placements and people at risk. Yet it is poorly ... -
APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
(2018-07)APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is considerable research interest in understanding whether APOE-ε4 influences cognition in healthy adults. Despite a substantial ... -
Care needs of people with dementia in the peri-operative environment: A systematic review
(2018-11)The care of people with dementia within the hospital setting is challenging for healthcare professionals. Hospital design and services are not optimized for people with dementia, owing to the lack of preparation of healthcare ... -
Barriers and facilitators to implementing dementia care mapping in care homes: results from the DCM™ EPIC trial process evaluation
(2019-02)Background: Psychosocial person-centred interventions are considered best practice for addressing complex behaviours and care needs such as agitation and anxiety, and for improving the quality of life of people with ... -
Valproate in dementia: time to move on? Commentary on…Cochrane Corner
(2019-02)Baillon et al ’s Cochrane review included 430 participants with agitation in dementia from five randomised controlled trials. Overall, the reviewers found that valproate was no better than placebo for the treatment of ... -
Memory tests for the diagnosis of MCI: A systematic review and meta-analysis
(2019-03)MCI is regarded as a prodrome to dementia, involving subjective memory complaint, greater forgetfulness than one would expect for age and intact activities of daily living in a patient not meeting criteria for dementia. ... -
Connections Between Insomnia and Cognitive Aging.
(2019-06)Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between insomnia and cognitive health is not well understood. Here, we review ... -
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
(2019-08)Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s ... -
Treatment for depression comorbid with dementia
(2019-11)Depression is a common comorbidity in dementia. Randomised controlled studies of antidepressants do not show a significant improvement in depressive symptoms in patients with comorbid dementia and are known to lead to an ... -
Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease A Randomized Clinical Trial
(2019-11)IMPORTANCE There are no disease-modifying treatments for Alzheimer disease (AD), the most common cause of dementia. Minocycline is anti-inflammatory, protects against the toxic effects of β-amyloid in vitro and in animal ... -
Evaluating the Feasibility of Frequent Cognitive Assessment Using the Mezurio Smartphone App: Observational and Interview Study in Adults With Elevated Dementia Risk
(2020-04)Background: By enabling frequent, sensitive, and economic remote assessment, smartphones will facilitate the detection of early cognitive decline at scale. Previous studies have sustained participant engagement with remote ... -
Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
(2020-04)Background Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia ... -
Vascular Dementia
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Are PROMs just for patients? Piloting the Long-Term Conditions Questionnaire for use with patients and carers in memory clinic settings
(2020-05)Background & Aims The Long-Term Conditions Questionnaire (LTCQ) was developed for assessing the overall impact of long-term health conditions (LTCs) on quality of life. Enhancing quality of life for people affected by ... -
Short-term memory advantage for brief durations in human APOE ε4 carriers
(2020-06)The Apolipoprotein-E (APOE) ε4 gene allele, the highest known genetic risk factor for Alzheimer’s disease, has paradoxically been well preserved in the human population. One possible explanation offered by evolutionary ... -
Health Outcome Prioritization in Alzheimer's Disease: Understanding the Ethical Landscape.
(2020-07)BACKGROUND:Dementia has been described as the greatest global health challenge in the 21st century on account of longevity gains increasing its incidence, escalating health and social care pressures. These pressures highlight ... -
The impact of assistive technology on burden and psychological well-being in informal caregivers of people with dementia (ATTILA Study)
(2020-09)Introduction: Assistive technology and telecare (ATT) may alleviate psychological burden in informal caregivers of people with dementia. This study assessed the impact of ATT on informal caregivers’ burden and psychological ... -
Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil
(2020-10)Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in ... -
Can dietary supplements maintain cognition in mid- to late-life?
(2020-12)Cognitive health, and prevention of its decline to dementia, has risen in prominence with a corresponding exploration of modifiable risk factors to prevent a decline in cognitive health with age. This commentary discusses ... -
Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
(2021-01)Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health record ...
