Browsing Drug Therapy by Issue Date
Now showing items 1-5 of 5
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Unbalanced risk-benefit analysis of ADHD drugs – Authors' reply
(2018)Standardised mean differences can be difficult to translate into clinical practice. As reported in the Cochrane handbook, the mean difference (or more correctly, difference in means) measures the absolute difference between ... -
Is placebo response in antidepressant trials rising or not? A reanalysis of datasets to conclude this long-lasting controversy
(2018-01)It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews ... -
A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry
(2018-07)There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding ... -
Mesolimbic Dopamine Function is Related to Salience Network Connectivity: An Integrative PET and MR Study
(2018-09-29)A wide range of neuropsychiatric disorders from schizophrenia to drug addiction involve abnormalities in both the mesolimbic dopamine system and the cortical salience network. Both systems play a key role in the detection ... -
Generating comparative evidence on new drugs and devices before approval
(2020-03)Fewer than half of new drugs have data on their comparative benefits and harms against existing treatment options at the time of regulatory approval in Europe and the USA. Even when active-comparator trials exist, they ...
