Browsing Neuroscience by Title
Now showing items 1-20 of 36
-
Age-related response speed deficits arise from specific impairments in sensory evidence accumulation rate
(2021-11)Older adults exposed to enriched environments (EE) maintain relatively higher levels of cognitive function, even in the face of compromised markers of brain health. Response speed (RS) is often used as a simple proxy to ... -
Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study
(2018-04-23)The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress ... -
Altered network stability in progressive supranuclear palsy
(2021-07)The clinical syndromes of Progressive Supranuclear Palsy (PSP) may be mediated by abnormal temporal dynamics of brain networks, due to the impact of atrophy, synapse loss and neurotransmitter deficits. We tested the ... -
Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age
(2020-08)Importance Prior neuroimaging studies have found that late-life participation in cognitive (eg, reading) and social (eg, visiting friends and family) leisure activities are associated with magnetic resonance imaging (MRI) ... -
Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies
(2019-08)There is increasing interest in factors that may modulate white matter (WM) breakdown and, consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor imaging studies have examined the relationship ... -
Challenges and future directions for representations of functional brain organization
(2020-10)A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent ... -
Clinical Prompt Learning with Frozen Language Models
(2022-05)Prompt learning is a new paradigm in the Natural Language Processing (NLP) field which has shown impressive performance on a number of natural language tasks with common benchmarking text datasets in full, few-shot, and ... -
Comparison of Cerebral Blood Flow in Regions Relevant to Cognition After Enzalutamide, Darolutamide, and Placebo in Healthy Volunteers: A Randomized Crossover Trial
(2023-05)Off-target central nervous system (CNS) effects are associated with androgen receptor (AR)-targeting treatments for prostate cancer. Darolutamide is a structurally distinct AR inhibitor with low blood–brain barrier ... -
Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe
(2020-03)Evolutionary adaptations of temporo-parietal cortex are considered to be a critical specialization of the human brain. Cortical adaptations, however, can affect different aspects of brain architecture, including local ... -
Delineating between-subject heterogeneity in alpha networks with Spatio-Spectral Eigenmodes
(2021-10)Between subject variability in the spatial and spectral structure of oscillatory networks can be highly informative but poses a considerable analytic challenge. Here, we describe a data-driven modal decomposition of a ... -
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
(2021-10)Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ... -
Dissecting Transient Burst Events
(2020-10)Increasing efforts are being made to understand the role of intermittent, transient, high-power burst events of neural activity. These events have a temporal, spectral, and spatial domain. Here, we argue that considering ... -
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
(2021-07)Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ... -
Effect of glucose and sucrose on cognition in healthy humans: a systematic review and meta-analysis of interventional studies
(2021-02)Evidence suggests that plasma glucose levels may influence cognitive performance, but this has not been systematically reviewed and quantified. Objective: The aim of this review was to investigate the potential effects of ... -
EMD: Empirical Mode Decomposition and Hilbert-Huang Spectral Analyses in Python
(2021-03)The Empirical Mode Decomposition (EMD) package contains Python (>=3.5) functions for analysis of non-linear and non-stationary oscillatory time series. EMD implements a family of sifting algorithms, instantaneous frequency ... -
Examining the Neural Correlates of Error Awareness in a Large fMRI Study
(2022-01)Goal-directed behaviour is dependent upon the ability to detect errors and implement appropriate post-error adjustments. Accordingly, several studies have explored the neural activity underlying error-monitoring processes, ... -
Functional biases in attentional templates from associative memory
(2020-12)In everyday life, attentional templates—which facilitate the perception of task-relevant sensory inputs—are often based on associations in long-term memory. We ask whether templates retrieved from memory are necessarily ... -
Generalizing Brain Decoding Across Subjects with Deep Learning
(2022-05)Decoding experimental variables from brain imaging data is gaining popularity, with applications in brain-computer interfaces and the study of neural representations. Decoding is typically subject-specific and does not ... -
Hierarchical modelling of functional brain networks in population and individuals from big fMRI data
(2021-02)A major goal of large-scale brain imaging datasets is to provide resources for investigating heterogeneous populations. Characterisation of functional brain networks for individual subjects from these datasets will have an ... -
Individual variation in brain microstructural-cognition relationships in aging
(2021-02)While all individuals are susceptible to age-related cognitive decline, significant inter- and intra-individual variability exists. However, the sources of this variation remain poorly understood. Here, we examined the ...
